Modulation of the B cell response to dengue virus infection by P. falciparum co-infection

Our study seeks to answer whether simultaneous infection (co-infection) with dengue virus and Plasmodium falciparum malaria interferes with the normal development of serum antibodies after dengue virus infection in Kenyan children. We will study, over time, the development of serum antibodies against dengue virus in children who become infected with the virus, as well as the B cells that are responsible for producing these antibodies. This study will help us understand how malaria infection might interfere with development of immunity after dengue virus infection, which would be important for planning of future vaccination efforts.

Funding provided by an NIAID Career Development Award (K23 AI127909, PI: David Vu) and an Instructor K Award Support Program Award from the Maternal & Child Health Research Institute and Department of Pediatrics at Stanford University School of Medicine (PI: David Vu).